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Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats
- Source :
- Laboratory Animal Research
- Publication Year :
- 2011
- Publisher :
- Korean Association for Laboratory Animal Science, 2011.
-
Abstract
- This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats were divided randomly into 3 groups: sham-operated group (sham), ovariectomized group (OVX) and SAC-treatment group (OVX+SAC). The OVX+SAC group was given drinking water containing 0.0012% SAC for 12 weeks. Bone breaking force and mineralization as well as blood parameters related to the bone metabolism were analyzed. In OVX animals, blood concentration of 17β-estradiol decreased significantly, while osteocalcin and type I collagen C-terminal telopeptides (CTx) increased. Breaking force, bone mineral density (BMD), calcium and phosphorus in femurs, as well as uterine and vaginal weights, decreased significantly following OVX. However, SAC treatment (0.0012% in drinking water) not only remarkably restored the decreased 17β-estradiol and increased osteocalcin and CTx concentrations, but also recovered decreased femoral breaking force, BMD, calcium and phosphorus, although it did not reversed reproductive organ weights. It is suggested that SAC effectively improve bone density by preventing bone turnover mediated osteocalcin, CTx and minerals, and that it could be a potential candidate for therapy or prevention of postmenopausal osteoporosis.
- Subjects :
- Bone mineral
medicine.medical_specialty
Bone density
biology
Osteoporosis
17β-estradiol
chemistry.chemical_element
osteocalcin
Calcium
medicine.disease
type I collagen C-terminal telopeptides
Bone remodeling
Endocrinology
chemistry
Internal medicine
Osteocalcin
biology.protein
medicine
Ovariectomized rat
Original Article
bone mineral density
Sigma Anti-bonding Molecule Calcium Carbonate
Type I collagen
Subjects
Details
- Language :
- English
- ISSN :
- 22337660 and 17386055
- Volume :
- 27
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Laboratory Animal Research
- Accession number :
- edsair.doi.dedup.....053ff758b973c68e2a4302c383b4b706