Back to Search
Start Over
Localization of gene expression for phosphatidylinositol transfer protein in the brain of developing and mature rats
- Source :
- Molecular Brain Research. 45:349-352
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- Gene expression for α - and β -isoforms of phosphatidylinositol transfer protein (PITP) was examined using in situ hybridization histochemistry in developing and mature rat brains. During embryonic and early post-natal stages, gene expression for both PITP- α and - β were detected widely throughout the entire neuraxis. In the adult brain, the expression for PITP- α was positive in almost all neurons throughout the entire brain while the expression for PITP- β markedly decreased in the entire gray matter regions except for the cerebellar cortex. By comparison with the previous findings on the expression for various molecules involved in the PI turnover, the present finding suggests that PITP is involved more intimately in some differentiation-related functions of immature neurons than those of mature neurons in co-operation with PI-related molecules and that PITPs exert their functions in adult brain in concert with PLCs in subtype-preferable inter-relation. © 1997 Elsevier Science B.V. All rights reserved.
- Subjects :
- Gene isoform
Aging
Transcription, Genetic
Central nervous system
In situ hybridization
Biology
Phosphatidylinositols
Embryonic and Fetal Development
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Gene expression
medicine
Animals
RNA, Messenger
Phosphatidylinositol
Phospholipid Transfer Proteins
Molecular Biology
Phosphatidylinositol transfer protein
Brain
Membrane Proteins
Embryonic stem cell
Rats
Cell biology
medicine.anatomical_structure
chemistry
Organ Specificity
Cerebellar cortex
Carrier Proteins
Neuroscience
Subjects
Details
- ISSN :
- 0169328X
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Molecular Brain Research
- Accession number :
- edsair.doi.dedup.....0526f189724d685cbd8ca8a96e5bb881