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Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors
- Source :
- Radiotherapy and Oncology. 89:222-226
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
- Subjects :
- Adult
Oncology
medicine.medical_specialty
Angiogenesis
DNA repair
Down-Regulation
Uterine Cervical Neoplasms
Immunoenzyme Techniques
Internal medicine
Cervical carcinoma
medicine
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
Hypoxia
Ku Autoantigen
P53 expression
Aged
Aged, 80 and over
Cervical cancer
Ku70
business.industry
Antigens, Nuclear
Hematology
Middle Aged
Hypoxia (medical)
medicine.disease
DNA-Binding Proteins
Tumor progression
Cancer research
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....05207e5f302fe7590402a90f1a8cb5d4
- Full Text :
- https://doi.org/10.1016/j.radonc.2008.07.018