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Baseline characteristics of infected foot ulcers in patients with diabetes at a tertiary care hospital in Pakistan
- Source :
- Journal of Wound Care. 27:S26-S32
- Publication Year :
- 2018
- Publisher :
- Mark Allen Group, 2018.
-
Abstract
- Objective: Studies on diabetic foot ulcers (DFU) involving a representative sample of patients in Pakistan are scarce. This study aimed to determine baseline characteristics of infected DFUs in patients hospitalised at the Pakistan Institute of Medical Sciences Islamabad. Method: In this cross-sectional study, carried out during May 2015 and June 2016, foot ulcer characteristics of patients with DFUs were investigated and documented. From infected DFUs, aerobic bacterial pathogens were isolated, identified and evaluated for antimicrobial susceptibility. Results: A total of 214 patients were recruited to the study, 62.6% of which were male, 90.2% were aged ≥40 years, 76.2% had type 1 diabetes and 78.5% had poor glycaemic control at time of presentation to hospital. Most patients had grade 3/moderate ulceration (based on the Wagner and International Working Group on the Diabetic Foot/Infectious Diseases Society of America criteria). Over half of the DFUs (57.9%) were of ≤3 months' duration and 70.1% were ≥3 cm2. Of the patients with deep infection grade ulcers, 26.6% underwent amputation, accounting for their prolonged hospital stay (≥20 days). Significant differences were observed between patients with type 1 and type 2 diabetes with DFUs in relation to gender (p≤0.0001), ulcer size (p=0.0421) and duration of hospital stay (p=0.0253). The most significant predictors for lower extremity amputation were osteomyelitis (p=0.0114), retinopathy (p=0.0001) and neuropathy (p=0.0001. Piperacillin/tazobactam was found to be an effective antibiotic against the most commonly isolated Staphylococcus non-aureus (35.48%), Pseudomonas aeruginosa (22.26%), and Staphylococcus aureus (20.96%) species indentified in the DFU infections. Conclusion: The findings of this study may be helpful in the optimal management and appropriate treatment of patients with infected DFUs.
- Subjects :
- Adult
Male
medicine.medical_specialty
Nursing (miscellaneous)
030209 endocrinology & metabolism
Microbial Sensitivity Tests
Gram-Positive Bacteria
Severity of Illness Index
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
Anti-Infective Agents
Diabetes mellitus
Internal medicine
Gram-Negative Bacteria
medicine
Humans
Pakistan
In patient
030212 general & internal medicine
Foot ulcers
business.industry
Tertiary care hospital
medicine.disease
Diabetic foot
Diabetic Foot
Cross-Sectional Studies
Diabetic foot ulcer
Diabetes Mellitus, Type 2
Baseline characteristics
Female
Fundamentals and skills
business
Subjects
Details
- ISSN :
- 20522916 and 09690700
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Journal of Wound Care
- Accession number :
- edsair.doi.dedup.....05127be03764adbdf3fa83f484d02606