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Clinical significance of cell cycle inhibitors in hepatocellular carcinoma
- Source :
- Medical Molecular Morphology. 46:185-192
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognostic biomarkers for various types of cancers. It has been reported that the main mechanism for p16 inactivation is aberrant DNA methylation, while p27 is exclusively inactivated by proteasome-mediated protein degradation. We have found that p27 is decreased in around half of hepatocellular carcinomas (HCCs), and in some cases p27 is inactivated by inappropriate interaction with cyclin D1/CDK4 complexes. In such cases, p16 is concomitantly inactivated through DNA methylation. Taking into consideration the complex interaction between p16 and p27, a comprehensive analysis including p16 and p27 would be useful for predicting the prognosis of HCC patients.
- Subjects :
- Oncology
medicine.medical_specialty
Carcinoma, Hepatocellular
Carcinogenesis
Protein degradation
Biology
Pathology and Forensic Medicine
Cyclin D1
Cyclin-dependent kinase
Internal medicine
Biomarkers, Tumor
medicine
Animals
Humans
Molecular Biology
Cyclin-Dependent Kinase Inhibitor p16
Kinase
Cell Cycle
Liver Neoplasms
General Medicine
Cell cycle
HCCS
Prognosis
medicine.disease
Hepatocellular carcinoma
DNA methylation
Cancer research
biology.protein
Cyclin-Dependent Kinase Inhibitor p27
Subjects
Details
- ISSN :
- 18601499 and 18601480
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Medical Molecular Morphology
- Accession number :
- edsair.doi.dedup.....051065989c9bc45ff53ff533e3f94da4