Treatment strategy for resectable colorectal cancer liver metastases from the viewpoint of time to surgical failure

The efficacy of pre or postoperative chemotherapy for resectable colorectal cancer liver metastases (CRLM) is disputed. This study aimed to examine the risk factors for time to surgical failure (TSF) and analyze the efficacy of pre or postoperative chemotherapy prior to liver resection for CRLM. The clinicopathological factors of 567 patients who underwent initial hepatectomy for CRLM at 7 university hospitals between April 2007 and March 2013 were retrospectively analyzed. The prognostic factors were identified and then stratified into two groups according to the number of preoperative prognostic factors: the high-score group (H-group, score 2–4) and the low-score group (L-group, score 0 or 1). Patients who experienced unresectable recurrence within 12 months after initial treatment had a significantly shorter prognosis than other patients (p