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A novel device for left atrial appendage exclusion
- Source :
- The Journal of Thoracic and Cardiovascular Surgery. 130(6):1639-1644
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Objective The left atrial appendage is a frequent source of thromboemboli in patients with atrial fibrillation. Exclusion or excision of the left atrial appendage may reduce the risk of stroke in patients with atrial fibrillation. We evaluated the ability of a novel device to exclude the left atrial appendage during early and intermediate follow-up periods in a canine model. Methods Eight mongrel dogs (mean weight 29.1 ± 4.0 kg) were used in this study. The occlusion device, constructed from 2 stainless steel strips covered with a knit braided polyester fabric, was implanted at the base of the left atrial appendage through a left thoracotomy on a beating heart. Dogs were evaluated at 7 days (n = 2), 30 days (n = 2), and 90 days (n = 4) by epicardial echocardiography, left atrial angiography, histologic inspection, and gross pathology. Results Device implantation was performed without complications in all animals. Complete exclusion of the left atrial appendage from the circulation was confirmed acutely and chronically by echocardiographic and angiographic evaluations. There was no device migration or damage to adjacent structures. Conclusion This novel device enables rapid, reliable, and safe exclusion of the left atrial appendage. The device provides a new therapeutic option for reducing the risk of stroke in patients with atrial fibrillation.
- Subjects :
- Thorax
Pulmonary and Respiratory Medicine
medicine.medical_specialty
medicine.medical_treatment
Atrial Appendage
Dogs
Internal medicine
Occlusion
medicine
Animals
cardiovascular diseases
Thoracotomy
Stroke
medicine.diagnostic_test
business.industry
Thrombosis
Atrial fibrillation
Equipment Design
Prostheses and Implants
medicine.disease
Surgery
Angiography
cardiovascular system
Cardiology
business
Cardiology and Cardiovascular Medicine
Subjects
Details
- ISSN :
- 00225223
- Volume :
- 130
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....04fa28fa89a19585f1fd0b6357fef9a7
- Full Text :
- https://doi.org/10.1016/j.jtcvs.2005.08.019