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Current Status and Challenges of Stem Cell Treatment for Alzheimer’s Disease
- Source :
- Journal of Alzheimer's Disease
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Neurodegenerative diseases called tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson’s disease, among others, are characterized by the pathological processing and accumulation of tau protein. AD is the most prevalent neurodegenerative disease and is characterized by two lesions: neurofibrillary tangles (NFTs) and neuritic plaques. The presence of NFTs in the hippocampus and neocortex in early and advanced stages, respectively, correlates with the patient’s cognitive deterioration. So far, no drugs can prevent, decrease, or limit neuronal death due to abnormal pathological tau accumulation. Among potential non-pharmacological treatments, physical exercise has been shown to stimulate the development of stem cells (SCs) and may be useful in early stages. However, this does not prevent neuronal death from the massive accumulation of NFTs. In recent years, SCs therapies have emerged as a promising tool to repopulate areas involved in cognition in neurodegenerative diseases. Unfortunately, protocols for SCs therapy are still being developed and the mechanism of action of such therapy remains unclear. In this review, we show the advances and limitations of SCs therapy. Finally, we provide a critical analysis of its clinical use for AD.
- Subjects :
- Amyloid
Tau protein
Neocortex
Plaque, Amyloid
tau Proteins
Review
Disease
amyloid-β
Hippocampus
tau protein
Progressive supranuclear palsy
Alzheimer Disease
Humans
Medicine
Senile plaques
neural stem cells
therapy
biology
business.industry
Stem Cells
General Neuroscience
Neurodegeneration
neurodegeneration
Neurofibrillary Tangles
General Medicine
medicine.disease
Psychiatry and Mental health
Clinical Psychology
medicine.anatomical_structure
nervous system
Government Regulation
biology.protein
Geriatrics and Gerontology
Stem cell
business
Alzheimer’s disease
Neuroscience
Frontotemporal dementia
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....04f5258c5dc29810b45b287b114a428e