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Human papillomavirus vaccine against cervical cancer: Opportunity and challenge
- Source :
- Cancer letters. 471
- Publication Year :
- 2019
-
Abstract
- Cervical cancer is one of the most common cancers threatening women's health, and the persistent infection of high-risk human papillomavirus (HPV) is closely related to the pathogenesis of cervical cancer and many other cancers. The carcinogenesis is a complex process from precancerous lesion to cancer, which provides an excellent window for clinical prevention, diagnosis, and treatment. However, despite the various preventions and treatments such as HPV screening, prophylactic HPV vaccines, surgery, radiotherapy, and chemotherapy, the disease burden remains heavy worldwide. Currently, three types of prophylactic vaccines, quadrivalent HPV vaccine, bivalent HPV vaccine, and a new nonavalent HPV vaccine, are commercially available. Although these vaccines are effective in protecting against 90% of HPV infection, they provide limited benefits to eliminate pre-existing infections. Therefore, new progress has been made in the development of therapeutic vaccines. Therapeutic vaccines differ from prophylactic vaccines in that they aim to stimulate cell-mediated immunity and kill the infected cells rather than neutralizing antibodies. This review aims at systematically covering the progress, current status and future prospects of various vaccines in development for the prevention and treatment of HPV-associated lesions and cancers and laying foundations for the development of the new original vaccine.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Uterine Cervical Neoplasms
HPV vaccines
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Immunity
Internal medicine
medicine
Humans
Papillomavirus Vaccines
Papillomaviridae
Disease burden
Randomized Controlled Trials as Topic
Cervical cancer
biology
business.industry
Papillomavirus Infections
HPV infection
medicine.disease
female genital diseases and pregnancy complications
Radiation therapy
030104 developmental biology
Clinical Trials, Phase III as Topic
030220 oncology & carcinogenesis
biology.protein
Female
Antibody
Carcinogenesis
business
Subjects
Details
- ISSN :
- 18727980
- Volume :
- 471
- Database :
- OpenAIRE
- Journal :
- Cancer letters
- Accession number :
- edsair.doi.dedup.....04f3ec84c20a16403d34d764fb8d97a0