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Biodegradable magnesium alloy (WE43) in bone‐fixation plate and screw
- Source :
- Journal of Biomedical Materials Research. Part B, Applied Biomaterials
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The purpose of the present study was to evaluate the mechanical strength and the absorption rate of WE43 material and to develop an absorbable metallic plate and screw for craniofacial application. The extruded WE43 plate and screw were evaluated using a LeFort I osteotomy canine model of 10 beagle dogs. Animals were divided into two groups: five dogs in the experimental group and five dogs in the control group. μCT was acquired at 4, 12, and 24 weeks. At 24 weeks after the operation, all animals were sacrificed, and histologic evaluation was performed. Swelling and gas formation were observed in three dogs in the experimental groups at 8 weeks. From 12 weeks, infraorbital fistula and inflammation were observed in three dogs in the experimental group, which gradually decreased and disappeared at 24 weeks. Other two dogs showed less gas formation at 12 weeks. The plates were completely absorbed, and gas formation was not observed at 24 weeks in these two dogs. New bone was well formed around the plates and screws in both groups. Histologic examination showed no specific differences between two groups. The mechanical strength of extruded WE43 was sufficient for mid‐facial application. Plates and screws made with appropriately treated WE43 have the potential to be useful clinically.
- Subjects :
- Materials science
Swine
medicine.medical_treatment
Bone fixation
Bone Screws
0206 medical engineering
Biomedical Engineering
Magnesium Compounds
Dentistry
02 engineering and technology
magnesium
Osteotomy
Beagle
Original Research Report
Craniofacial Abnormalities
Biomaterials
Absorption rate
Fracture Fixation, Internal
biocompatibility
Dogs
Original Research Reports
Gas formation
Absorbable Implants
Alloys
medicine
Animals
Craniofacial
Mechanical Phenomena
business.industry
absorbable plate and screw
X-Ray Microtomography
WE43
021001 nanoscience & nanotechnology
020601 biomedical engineering
Corrosion
Biodegradable magnesium
Swine, Miniature
Swelling
medicine.symptom
0210 nano-technology
business
bone‐fixation plate and screw
Bone Plates
Subjects
Details
- ISSN :
- 15524981 and 15524973
- Volume :
- 108
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Accession number :
- edsair.doi.dedup.....04ed23bef93691dcc49953e7b4b4b12b