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A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
- Source :
- Cell Reports Medicine, Vol 2, Iss 4, Pp 100230-(2021), Cell Reports Medicine, bioRxiv
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The deployment of a vaccine that limits transmission and disease likely will be required to end the Coronavirus Disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally-administered chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike (S) protein (ChAd-SARS-CoV-2-S) in the upper and lower respiratory tract of mice expressing the human angiotensin-converting enzyme 2 (ACE2) receptor. Here, we show the immunogenicity and protective efficacy of this vaccine in non-human primates. Rhesus macaques were immunized with ChAd-Control or ChAd-SARS-CoV-2-S and challenged one month later by combined intranasal and intrabronchial routes with SARS-CoV-2. A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tract after SARS-CoV-2 challenge. As this single intranasal dose vaccine confers protection against SARS-CoV-2 in non-human primates, it is a promising candidate for limiting SARS-CoV-2 infection and transmission in humans.<br />Graphical Abstract<br />Hassan et al show that a single dose immunization of rhesus monkeys with ChAd-SARS-CoV-2-S via an intranasal route induces neutralizing antibodies and T cell responses against SARS-CoV-2. ChAd-SARS-CoV-2-S vaccine protects rhesus monkeys against SARS-CoV-2 infection in both the upper and lower respiratory tracts.
- Subjects :
- Medicine (General)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
T cell
viruses
mucosal
immunogenicity
Article
General Biochemistry, Genetics and Molecular Biology
Viral vector
R5-920
Immunity
Report
vaccine
parasitic diseases
Medicine
Receptor
skin and connective tissue diseases
biology
business.industry
Transmission (medicine)
SARS-CoV-2
Immunogenicity
fungi
virus diseases
Virology
immunity
body regions
medicine.anatomical_structure
biology.protein
Nasal administration
Antibody
non-human primates
business
Respiratory tract
Subjects
Details
- Language :
- English
- ISSN :
- 26663791
- Volume :
- 2
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cell Reports Medicine
- Accession number :
- edsair.doi.dedup.....04d9bc020cbff5ee83f2c6ef16878b99