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The big reveal: Family disclosure patterns of BRCA genetic test results among young Black women with invasive breast cancer
- Source :
- J Genet Couns
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Despite higher incidence and mortality of breast cancer among younger Black women, genetic testing outcomes remain severely understudied among Blacks. Past research on disclosure of genetic testing results to family members has disproportionately focused on White, educated, high socioeconomic status women. This study addresses this gap in knowledge by assessing (1) to whom Black women disclose genetic test results and (2) if patterns of disclosure vary based on test result (e.g., BRCA1/2 positive, negative, variant of uncertain significance [VUS]). Black women (N=149) with invasive breast cancer diagnosed age ≤50 years from 2009–2012 received free genetic testing through a prospective, population-based study. At 12 months post-testing, women reported with whom they shared their genetic test results. The exact test by binomial distribution was used to examine whether disclosure to female relatives was significantly greater than disclosure to male relatives, and logistic regression analyses tested for differences in disclosure to any female relative, any male relative, parents, siblings, children, and spouses by genetic test result. Most (77%) women disclosed their results to at least one family member. Disclosure to female relatives was significantly greater than disclosure to males (p0.12). Results suggest that in Black families, one benefit of genetic testing – to inform patients and their family with cancer risk information – is not being realized. To increase breast cancer preventive care among high-risk Black women, the oncology care team should prepare Black BRCA1/2 positive women to share genetic test results with family members and, in particular, their daughters.
- Subjects :
- Adult
Male
Genetic counseling
Genes, BRCA2
Population
Genes, BRCA1
Breast Neoplasms
Disclosure
Truth Disclosure
Logistic regression
Article
03 medical and health sciences
0302 clinical medicine
Breast cancer
Humans
Medicine
Family
Neoplasm Invasiveness
Genetic Testing
Child
education
Socioeconomic status
Genetics (clinical)
Genetic testing
0303 health sciences
education.field_of_study
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
030305 genetics & heredity
Middle Aged
medicine.disease
Black or African American
Exact test
030220 oncology & carcinogenesis
Female
business
Demography
Subjects
Details
- ISSN :
- 15733599 and 10597700
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Genetic Counseling
- Accession number :
- edsair.doi.dedup.....04d3072ba203cae9bfeb8240625d9177