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Clinical characteristics and outcomes of COVID‐19 in patients with type 2 diabetes in Turkey: A nationwide study (TurCoviDia)
- Source :
- Journal of Diabetes
- Publication Year :
- 2021
- Publisher :
- Wiley Publishing Asia Pty Ltd, 2021.
-
Abstract
- Background Coronavirus disease 2019 (COVID‐19) has been reported to be associated with a more severe course in patients with type 2 diabetes mellitus (T2DM). However, severe adverse outcomes are not recorded in all patients. In this study, we assessed disease outcomes in patients with and without T2DM hospitalized for COVID‐19. Methods A nationwide retrospective cohort of patients with T2DM hospitalized with confirmed COVID‐19 infection from 11 March to 30 May 2020 in the Turkish Ministry of Health database was investigated. Multivariate modeling was used to assess the independent predictors of demographic and clinical characteristics with mortality, length of hospital stay, and intensive care unit (ICU) admission and/or mechanical ventilation. Results A total of 18 426 inpatients (median age [interquartile range, IQR]: 61 [17] years; males: 43.3%) were investigated. Patients with T2DM (n = 9213) were compared with a group without diabetes (n = 9213) that were matched using the propensity scores for age and gender. Compared with the group without T2DM, 30‐day mortality following hospitalization was higher in patients with T2DM (13.6% vs 8.7%; hazard ratio 1.75; 95% CI, 1.58‐1.93; P<br />Highlights Coronavirus disease 2019 (COVID‐19) takes an unfavorable course in patients with type 2 diabetes mellitus (T2DM), and the risk increases in individuals with certain conditions, some of which are not modifiable.This study showed significantly higher mortality due to COVID‐19 in hospitalized patients with T2DM than without (13.6% vs 8.7%; hazard ratio 1.75; 95% CI, 1.58‐1.93).Older age, male gender, obesity, preexisting insulin treatment, low lymphocyte count, and pulmonary involvement on admission were the significant associates of COVID‐19 mortality.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Turkey
Endocrinology, Diabetes and Metabolism
intensive care unit admission
030209 endocrinology & metabolism
Type 2 diabetes
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
0302 clinical medicine
Interquartile range
law
COVID‐19
Internal medicine
Diabetes mellitus
Outcome Assessment, Health Care
Medicine
Humans
Epidemics
Aged
Retrospective Studies
Glycated Hemoglobin
business.industry
SARS-CoV-2
Hazard ratio
Type 2 Diabetes Mellitus
COVID-19
Retrospective cohort study
Original Articles
Length of Stay
Middle Aged
medicine.disease
Intensive care unit
mortality
Respiration, Artificial
hospital stay
Hospitalization
Intensive Care Units
Diabetes Mellitus, Type 2
Propensity score matching
Original Article
Female
type 2 diabetes
business
Subjects
Details
- Language :
- English
- ISSN :
- 17530407 and 17530393
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes
- Accession number :
- edsair.doi.dedup.....04ccbb5d54d662dba330794915228b43