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Diminished prefrontal brain function in adults with psychopathology in childhood related to attention deficit hyperactivity disorder
- Source :
- Psychiatry research. 138(2)
- Publication Year :
- 2003
-
Abstract
- The aim of the present study was to investigate prefrontal brain function and cognitive response control in patients with personality disorders who either suffered or did not suffer from psychopathology related to attention deficit hyperactivity disorder (ADHD) during childhood. For this purpose, 36 psychiatric out-patients with personality disorders--24 of whom showed ADHD-related psychopathology during childhood assessed by the German short form of the Wender Utah Rating Scale--and 24 healthy controls were investigated electrophysiologically by means of a cued Go-NoGo task (Continuous Performance Test). Topographical analyses were conducted to individually quantify the NoGo anteriorisation (NGA), a neurophysiological correlate of prefrontal response control that has been suggested to reflect activation of the anterior cingulate cortex. ADHD patients exhibited a significantly reduced mean NGA and diminished amplitudes of the Global Field Power, as well as a reduced increase of fronto-central P300 amplitudes, in NoGo-trials compared with the healthy controls, whereas patients with personality disorders alone did not differ from the control group in any of the electrophysiological parameters. The results indicate that ADHD-related psychopathology is associated with prefrontal brain dysfunction, probably related to processes of response inhibition and/or cognitive response control.
- Subjects :
- Adult
Male
medicine.medical_specialty
Psychometrics
media_common.quotation_subject
Neuroscience (miscellaneous)
Prefrontal Cortex
Audiology
Gyrus Cinguli
Event-related potential
mental disorders
medicine
Personality
Attention deficit hyperactivity disorder
Humans
Radiology, Nuclear Medicine and imaging
Psychiatry
Anterior cingulate cortex
media_common
Cued speech
Electroencephalography
medicine.disease
Personality disorders
Event-Related Potentials, P300
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
Electrophysiology
medicine.anatomical_structure
Attention Deficit Disorder with Hyperactivity
Female
Psychology
Psychomotor Performance
Psychopathology
Subjects
Details
- ISSN :
- 01651781
- Volume :
- 138
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Psychiatry research
- Accession number :
- edsair.doi.dedup.....04a2a3e9eaecf5b137dd8d2e79df8218