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Rapid Prototyping of Miniaturized Powder Mixing Geometries

Authors :
Troels Pedersen
Rasmus Svane
Jukka Rantanen
Cosima Hirschberg
Source :
Svane, R, Pedersen, T, Hirschberg, C & Rantanen, J 2021, ' Rapid Prototyping of Miniaturized Powder Mixing Geometries ', Journal of Pharmaceutical Sciences, vol. 110, no. 7, pp. 2625-2628 . https://doi.org/10.1016/j.xphs.2021.03.019
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

Details

ISSN :
00223549
Volume :
110
Database :
OpenAIRE
Journal :
Journal of Pharmaceutical Sciences
Accession number :
edsair.doi.dedup.....0493e6aa0f4785555108fa1386f36772