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Rapid Prototyping of Miniaturized Powder Mixing Geometries
- Source :
- Svane, R, Pedersen, T, Hirschberg, C & Rantanen, J 2021, ' Rapid Prototyping of Miniaturized Powder Mixing Geometries ', Journal of Pharmaceutical Sciences, vol. 110, no. 7, pp. 2625-2628 . https://doi.org/10.1016/j.xphs.2021.03.019
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.
- Subjects :
- Rapid prototyping
Computer science
media_common.quotation_subject
Pharmaceutical Science
3D printing
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
0302 clinical medicine
Inline monitoring
Technology, Pharmaceutical
Quality (business)
Multivariate data analysis
Process engineering
Mixing (physics)
Residence time distribution (RTD)
media_common
Process analytical technology (PAT)
Spectrometer
business.industry
Process (computing)
Continuous manufacturing
021001 nanoscience & nanotechnology
Residence time distribution
Powders
0210 nano-technology
business
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....0493e6aa0f4785555108fa1386f36772