Back to Search
Start Over
Role of epithelial HCO3− transport in mucin secretion: lessons from cystic fibrosis
- Source :
- American Journal of Physiology-Cell Physiology. 299:C1222-C1233
- Publication Year :
- 2010
- Publisher :
- American Physiological Society, 2010.
-
Abstract
- The invitation to present the 2010 Hans Ussing lecture for the Epithelial Transport Group of the American Physiological Society offered me a unique, special, and very surprising opportunity to join in saluting a man whom I met only once, but whose work was the basis, not only for my career, but also for finding the molecular defect in the inherited disease cystic fibrosis (CF). In this context, I will venture to make the tribute with a new explanation of why a mutation in a single gene that codes for an anion channel can cause devastation of multiple epithelial systems with pathogenic mucus. In so doing, I hope to raise awareness of a new role for that peculiar anion around which so much physiology revolves, HCO3−. I begin by introducing CF pathology as I question the name of the disease as well as the prevalent view of the basis of its pathology by considering: 1) mucus, 2) salt, and 3) HCO3−. I then present recent data showing that HCO3− is required for normal mucus discharge, and I will close with conjecture as to how HCO3− may support mucus discharge and why the failure to transport this electrolyte is pathogenic in CF.
- Subjects :
- Male
medicine.medical_specialty
Cystic Fibrosis
Physiology
Cystic Fibrosis Transmembrane Conductance Regulator
Reviews
Context (language use)
Sodium Chloride
Biology
Cystic fibrosis
Mice
Internal medicine
medicine
Animals
Humans
Mucin secretion
Lung
Ion Transport
Mucin
Mucins
Cell Biology
respiratory system
medicine.disease
Mucus
Cystic fibrosis transmembrane conductance regulator
Sweat Glands
Bicarbonates
Endocrinology
Immunology
biology.protein
Female
Inherited disease
Mucus discharge
Subjects
Details
- ISSN :
- 15221563 and 03636143
- Volume :
- 299
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Cell Physiology
- Accession number :
- edsair.doi.dedup.....048fd720d5b534b40ed31b01a79c484e