Back to Search
Start Over
The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells
- Source :
- Neuroreport. 9(13)
- Publication Year :
- 1998
-
Abstract
- Fenfluramine is an amphetamine analogue which has been widely used in the treatment of obesity. In rodents, non-human primates, and humans, fenfluramine is associated with some indices of neurotoxicity, as well as pulmonary hypertension and cardiac valve pathology. In the present study, d-fenfluramine was found to be cytotoxic to the serotonin (5-HT) transporter (5-HTT) expressing human placental choriocarcinoma cells. d-Fenfluramine caused DNA fragmentation and apoptosis. Apoptosis was not observed after the 5-HTT had been blocked by fluoxetine, indicating that intact 5-HTT function is required for d-fenfluramine to induce programmed cell death. These observations in a human cell line may reflect a possible mechanism associated with the risks of fenfluramine administration in several species, including humans.
- Subjects :
- Programmed cell death
medicine.medical_specialty
Serotonin
Time Factors
Fenfluramine
Apoptosis
Nerve Tissue Proteins
DNA Fragmentation
Biology
Serotonergic
Serotonin Agents
Internal medicine
Fluoxetine
Appetite Depressants
medicine
Tumor Cells, Cultured
Humans
Choriocarcinoma
Amphetamine
Cell Size
Cell Nucleus
Serotonin Plasma Membrane Transport Proteins
Membrane Glycoproteins
Dose-Response Relationship, Drug
General Neuroscience
Neurotoxicity
Membrane Transport Proteins
Biological Transport
medicine.disease
Endocrinology
Anorectic
Female
Carrier Proteins
medicine.drug
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 9
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Neuroreport
- Accession number :
- edsair.doi.dedup.....048a8009f43491d31088b47544544eda