A new lead to NLRP3 inhibition

Authors :: Mohamed Lamkanfi
Vishva M. Dixit
Source :: The Journal of Experimental Medicine
Publication Year :: 2017
Publisher :: Rockefeller University Press, 2017.
Abstract: The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al.).<br />The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).