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Design and evaluation of Raman reporters for the Raman-silent region
Design and evaluation of Raman reporters for the Raman-silent region
- Source :
- Nanotheranostics
- Publication Year :
- 2022
- Publisher :
- Ivyspring International Publisher, 2022.
-
Abstract
- Rationale: Surface enhanced Raman scattering (SERS) is proving to be a useful tool for biomedical imaging. However, this imaging technique can suffer from poor signal-to-noise ratio, as the complexity of biological tissues can lead to overlapping of Raman bands from tissues and the Raman reporter molecule utilized. Methods: Herein we describe the synthesis of triple bond containing Raman reporters that scatter light in the biological silent window, between 1750 cm-1 and 2750 cm-1. Results: Our SERS nanoprobes are comprised of uniquely designed Raman reporters containing either alkyne- or cyano-functional groups, enabling them to be readily distinguished from background biological tissue. Conclusion: We identify promising candidates that eventually can be moved forward as Raman reporters in SERS nanoparticles for highly specific contrast-enhanced Raman-based disease or analyte detection in biological applications.
Details
- ISSN :
- 22067418
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Nanotheranostics
- Accession number :
- edsair.doi.dedup.....047886a4676b7ddeff566700c3055d96
- Full Text :
- https://doi.org/10.7150/ntno.58965