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Design and evaluation of Raman reporters for the Raman-silent region

Design and evaluation of Raman reporters for the Raman-silent region

Authors :
Konstantinos Plakas
Lauren E. Rosch
Michael D. Clark
Shukree Adbul-Rashed
Travis M. Shaffer
Stefan Harmsen
Sanjiv S. Gambhir
Michael R. Detty
Source :
Nanotheranostics
Publication Year :
2022
Publisher :
Ivyspring International Publisher, 2022.

Abstract

Rationale: Surface enhanced Raman scattering (SERS) is proving to be a useful tool for biomedical imaging. However, this imaging technique can suffer from poor signal-to-noise ratio, as the complexity of biological tissues can lead to overlapping of Raman bands from tissues and the Raman reporter molecule utilized. Methods: Herein we describe the synthesis of triple bond containing Raman reporters that scatter light in the biological silent window, between 1750 cm-1 and 2750 cm-1. Results: Our SERS nanoprobes are comprised of uniquely designed Raman reporters containing either alkyne- or cyano-functional groups, enabling them to be readily distinguished from background biological tissue. Conclusion: We identify promising candidates that eventually can be moved forward as Raman reporters in SERS nanoparticles for highly specific contrast-enhanced Raman-based disease or analyte detection in biological applications.

Details

ISSN :
22067418
Volume :
6
Database :
OpenAIRE
Journal :
Nanotheranostics
Accession number :
edsair.doi.dedup.....047886a4676b7ddeff566700c3055d96
Full Text :
https://doi.org/10.7150/ntno.58965