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Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma
- Source :
- Cancer Medicine, Vol 8, Iss 5, Pp 2146-2156 (2019), Cancer Medicine
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported. Objectives To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan-Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease-specific survival in patients with invasive melanoma. Results In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4%) followed by superficial spreading melanoma (20.5%), nodular melanoma (10.0%), mucosal melanoma (9.5%), and lentigo maligna melanoma (8.1%). The 5-year disease-specific survival for each stage was as follows: IA = 98.0%, IB = 93.9%, IIA = 94.8%, IIB = 82.4%, IIC = 71.8%, IIIA = 75.0%, IIIB = 61.3%, IIIC = 41.7%, and IV = 17.7%. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions Our study revealed the characteristics of melanoma in the Japanese population. The 5-year disease-specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Skin Neoplasms
Adolescent
Epidemiology
mucosal
Kaplan-Meier Estimate
Nodular melanoma
Acral lentiginous melanoma
lcsh:RC254-282
03 medical and health sciences
Young Adult
0302 clinical medicine
Asian People
Japan
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Lentigo maligna melanoma
Child
Melanoma
Survival analysis
Original Research
Aged
Proportional Hazards Models
Aged, 80 and over
acral
Asian
business.industry
Mucosal melanoma
Clinical Cancer Research
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Superficial spreading melanoma
030104 developmental biology
030220 oncology & carcinogenesis
Child, Preschool
Japanese
Female
Skin cancer
business
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....046b51d2ac0477e7ca21aada746b3fbb