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Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae
- Source :
- Journal of Bacteriology. 176:4448-4454
- Publication Year :
- 1994
- Publisher :
- American Society for Microbiology, 1994.
-
Abstract
- Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases.
- Subjects :
- Operon
Mitomycin
Molecular Sequence Data
Microbiology
Open Reading Frames
chemistry.chemical_compound
Bacterial Proteins
Amino Acid Sequence
RNA, Messenger
Cloning, Molecular
Molecular Biology
Gene
Peptide sequence
Genetics
Base Sequence
biology
Streptomycetaceae
Mitomycin C
Nucleic acid sequence
Drug Resistance, Microbial
Oxidoreductases, N-Demethylating
Sequence Analysis, DNA
biology.organism_classification
Streptomyces
Blotting, Southern
RNA, Bacterial
Biochemistry
chemistry
Streptomyces lavendulae
Trans-Activators
Oxidoreductases
Sequence Alignment
L-Gulonolactone Oxidase
DNA
Sugar Alcohol Dehydrogenases
Research Article
Subjects
Details
- ISSN :
- 10985530 and 00219193
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- Journal of Bacteriology
- Accession number :
- edsair.doi.dedup.....04656c637d351cbcb4dcd621354d3b4f