Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

Authors :: Nicola Demitri
Maria Kuzikov
Barbara Giabbai
Elisa Costanzi
Andrea Zaliani
Giulia Rossetti
Simone Albani
Paola Storici
Enzo Tramontano
Francesca Esposito
Marianna Camasta
Publica
Source :: International Journal of Molecular Sciences, Volume 22, Issue 21, International journal of molecular sciences 22(21), 11779 (2021). doi:10.3390/ijms222111779 special issue: "Topical Collection "Feature Papers in Molecular Pharmacology" / Editor: Prof. Dr. Peter Illes, Collection Editor", International Journal of Molecular Sciences, Vol 22, Iss 11779, p 11779 (2021), International journal of molecular sciences 22(21), 11779-(2021). doi:10.3390/ijms222111779
Publication Year :: 2021
Publisher :: Multidisciplinary Digital Publishing Institute, 2021.
Abstract: International journal of molecular sciences 22(21), 11779 (2021). doi:10.3390/ijms222111779 special issue: "Topical Collection "Feature Papers in Molecular Pharmacology" / Editor: Prof. Dr. Peter Illes, Collection Editor"<br />Published by Molecular Diversity Preservation International, Basel

Subjects :: Peptidomimetic
Leupeptins
Protein Conformation
medicine.medical_treatment
Cathepsin L
Plasma protein binding
Virus Replication
0302 clinical medicine
Protein structure
X-Ray Diffraction
Catalytic Domain
Drug Discovery
Biology (General)
MG-132
Spectroscopy
Coronavirus 3C Proteases
0303 health sciences
biology
Chemistry
Drug discovery
General Medicine
Mpro/3CLPro
3. Good health
Computer Science Applications
Molecular Docking Simulation
Biochemistry
030220 oncology & carcinogenesis
ddc:540
Protein Binding
QH301-705.5
In silico
Molecular Dynamics Simulation
Antiviral Agents
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
medicine
Humans
Protein Interaction Domains and Motifs
Physical and Theoretical Chemistry
dual target inhibitor
Molecular Biology
QD1-999
030304 developmental biology
Protease
SARS-CoV-2
Organic Chemistry
Cathepsin-L
COVID-19 Drug Treatment
Docking (molecular)
Drug Design
peptidomimetics
biology.protein

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