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Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2003
- Publisher :
- Rockefeller University Press, 2003.
-
Abstract
- The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366–374/Db- and PA224–233/Db-specific CD8+ T cells respond in approximately equal numbers to a primary influenza virus infection in C57BL/6 mice, whereas NP366–374/Db-specific CD8+ T cells dominate the secondary response. To investigate the mechanisms underlying this changing pattern of immunodominance, we analyzed the role of antigen presentation in regulating the specificity of the T cell response. The data show that both dendritic and nondendritic cells are able to present the NP366–374/Db epitope, whereas only dendritic cells effectively present the PA224–233/Db epitope after influenza virus infection, both in vitro and in vivo. This difference in epitope expression favored the activation and expansion of NP366–374/Db-specific CD8+ memory T cells during secondary infection. The data also show that the immune response to influenza virus infection may involve T cells specific for epitopes, such as PA224–233/Db, that are poorly expressed at the site of infection. In this regard, vaccination with the PA224–233 peptide actually had a detrimental effect on the clearance of a subsequent influenza virus infection. Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies.
- Subjects :
- Secondary infection
T cell
Immunology
Orthomyxoviridae
Antigen presentation
Immunodominance
CD8-Positive T-Lymphocytes
Article
Epitope
Cell Line
Epitopes
Mice
03 medical and health sciences
0302 clinical medicine
Orthomyxoviridae Infections
medicine
antigen-presenting cells
Animals
Immunology and Allergy
Cytotoxic T cell
Antigen-presenting cell
Antigens, Viral
030304 developmental biology
Antigen Presentation
0303 health sciences
immunologic memory
biology
Immunodominant Epitopes
Viral Core Proteins
CD8-positive T lymphocytes
Dendritic Cells
biology.organism_classification
Virology
Peptide Fragments
3. Good health
Mice, Inbred C57BL
medicine.anatomical_structure
Female
influenza
030215 immunology
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 198
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....045d20eed4cd578aaa4909a71b00819e