Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

Authors :: Thomas Efferth
Eman G. Haggag
Hisashi Matsuda
Paul W. Paré
Faiza Hammouda
Mahmoud A. A. Ibrahim
Ahmed R. Hamed
Seikou Nakamura
Eman H. Reda
Mohamed-Elamir F. Hegazy
Nahla S. Abdel-Azim
Zienab Talat
Source :: Molecules, Vol 23, Iss 9, p 2221 (2018), Molecules, Volume 23, Issue 9
Publication Year :: 2018
Publisher :: MDPI AG, 2018.
Abstract: Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1&ndash<br />4) as well as previously reported metabolites (5&ndash<br />13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 &micro<br />M). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.

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