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A Novel and Accurate Computer Model of Melanoma Prognosis for Patients Staged by Sentinel Lymph Node Biopsy: Comparison with the American Joint Committee on Cancer Model
- Source :
- Journal of the American College of Surgeons. 214:608-617
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Background We found that a computer model developed by the American Joint Committee on Cancer (AJCC) melanoma staging committee had limitations for predicting prognosis of patients staged by sentinel lymph node (SLN) biopsy. We sought to develop a model that more accurately predicts prognosis in this population. Study Design Using a data set obtained from a prospective multi-institutional study of 2,507 patients with clinically node-negative melanomas ≥1.0 mm Breslow thickness, we developed a prognostic model using a Cox regression formula incorporating a number of significant clinicopathologic factors. The AJCC model and our model were used to predict 5-year survival from this test data set. The concordance correlation coefficient (CCC) was determined and chi-square tests were performed. Our new prognostic model was validated using an independent data set of 1,001 patients. Results Using the test data set, the CCC for the AJCC model was 0.875; chi-square tests demonstrated statistically significant differences between observed and predicted survivals for numerous clinicopathologic factors. The CCC for our model was 0.976 and none of the chi-square tests was statistically significant. Our model performed similarly well in SLN-negative patients (CCC 0.929) and SLN-positive patients (CCC 0.889). The AJCC model performed well in SLN-negative patients (CCC 0.854), but not in SLN-positive patients (CCC 0.626). Using the validation data set, similar findings were obtained. Conclusions Our prognostic model provides superior survival estimates compared with the AJCC model for patients undergoing SLN biopsy. This online tool is available at www.melanomacalculator.com, and will provide important information that can be used to guide adjuvant therapy decisions and stratification in clinical trials.
- Subjects :
- Adult
Male
medicine.medical_specialty
Skin Neoplasms
Adolescent
Cancer Model
Population
Sentinel lymph node
Models, Biological
Risk Assessment
Decision Support Techniques
Cohort Studies
Young Adult
Adjuvant therapy
medicine
Humans
Computer Simulation
education
Melanoma
Aged
Neoplasm Staging
Proportional Hazards Models
education.field_of_study
Chi-Square Distribution
Sentinel Lymph Node Biopsy
Proportional hazards model
business.industry
Middle Aged
Prognosis
medicine.disease
Surgery
Concordance correlation coefficient
Female
Radiology
business
Chi-squared distribution
Subjects
Details
- ISSN :
- 10727515
- Volume :
- 214
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Surgeons
- Accession number :
- edsair.doi.dedup.....044e9f5b057525c405c0ea2f1e61f859