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Adjuvant chemotherapy does not provide survival benefits to elderly patients with stage II colon cancer
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- To date, the effect of adjuvant chemotherapy after curative resection in patients with stage II colon cancer remains controversial. Still, little is known about the effects of adjuvant chemotherapy in patients with stage II colon cancer who are older than 70 years, as most studies did not focus on this population. This study aimed to investigate the oncologic outcomes of elderly patients with stage II colon cancer who underwent curative resection with or without postoperative adjuvant chemotherapy. We retrospectively reviewed medical records of patients older than 70 years who underwent curative resection of stage II primary colon cancer during 2002–2015. Patients were classified into surgery alone (SA) and adjuvant chemotherapy (AC) groups and propensity score-matched at a 1:1 ratio using a logistic regression. The end points were recurrence-free (RFS), cancer-specific (CSS) and overall survival (OS). Of the 623 patients who met the criteria, 145 were assigned to each arm after propensity score matching. The mean ages of the SA and AC groups were 74.3 and 74.0 years, respectively. A log-rank test revealed no significant inter-group differences in RFS (p = 0.202), CSS (p = 0.486) or OS (p = 0.299). In a Cox regression analysis, adjuvant chemotherapy was not found to be an independent factor affecting RFS (p = 0.206), CSS (p = 0.487) or OS (p = 0.301). Adjuvant chemotherapy does not appear to yield survival benefits in elderly patients with stage II colon cancer.
- Subjects :
- Male
0301 basic medicine
Oncology
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Population
lcsh:Medicine
Kaplan-Meier Estimate
Disease-Free Survival
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Propensity Score
education
lcsh:Science
Survival analysis
Aged
Neoplasm Staging
Aged, 80 and over
Chemotherapy
education.field_of_study
Multidisciplinary
Proportional hazards model
business.industry
Medical record
lcsh:R
medicine.disease
Survival Analysis
Colon cancer
030104 developmental biology
Chemotherapy, Adjuvant
Surgical oncology
Colonic Neoplasms
Multivariate Analysis
Propensity score matching
Female
lcsh:Q
business
Adjuvant
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....04497a97c9009ab4a1a310afd3f76343