Back to Search
Start Over
Laser-induced fluorescent visualization and photodynamic therapy in surgical treatment of glial brain tumors
- Source :
- Biomed Opt Express
- Publication Year :
- 2021
- Publisher :
- Optical Society of America, 2021.
-
Abstract
- High-grade gliomas have a diffuse and infiltrative nature of the growth of tumor cells, due to which the achievement of radical resection is difficult. Surgical resection completeness of brain tumors is an important factor in prolonging the life of patients. An accurate definition of tumor boundaries and residual fluorescent regions is impossible due to imperfections of the equipment used for fluorescent imaging. 5-aminolevulinic acid (5-ALA) is a precursor of protoporphyrin IX (PpIX) in humans and is clinically used to detect and treat tumors. Currently, fluorescence-guided surgery with PpIX used a surgical microscope with an excitation wavelength in the blue spectrum range. Because of its low ability to penetrate into biological tissue, blue light is ineffective for providing high-quality fluorescent navigation. Also, when performing an operation using radiation in the blue spectrum range, the photosensitizer’s surface layer (PS) often bleaches out, which leads to frequent errors. The use of red light emission makes it possible to slow down the PS bleaches out due to the absorption properties of PpIX, but this task is technically more complicated and requires highly sensitive cameras and specialized optical filters. The new two-channel video system for fluorescent navigation has a radiation source in the red range of the spectrum, the penetration depth of which is greater than the blue light, which makes it possible to increase the depth of probing into biological tissues. The study’s clinical part involved 5 patients with high grade glioma and 1 patient with low grade glioma: grade III oligodendrogliomas (2), grade IV glioblastomas (3), and grade II diffusion astrocytoma (1).
- Subjects :
- 0303 health sciences
Protoporphyrin IX
medicine.medical_treatment
Astrocytoma
Photodynamic therapy
Laser
medicine.disease
Fluorescent imaging
01 natural sciences
Fluorescence
Atomic and Molecular Physics, and Optics
Article
law.invention
010309 optics
03 medical and health sciences
chemistry.chemical_compound
chemistry
law
0103 physical sciences
medicine
Photosensitizer
Surgical treatment
030304 developmental biology
Biotechnology
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biomed Opt Express
- Accession number :
- edsair.doi.dedup.....0447a95ccfbe91e041c1d5293521054e