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The Effect of Ageing on Clinical, Hormonal and Sonographic Features Associated with PCOS-A Long-Term Follow-Up Study
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 2101, p 2101 (2021), Volume 10, Issue 10
- Publication Year :
- 2021
-
Abstract
- The knowledge of polycystic ovary syndrome (PCOS) natural history is limited. Our objective was to assess the effect of aging on clinical, hormonal and sonographic ovarian PCOS features and additionally to identify parameters that impact the course of PCOS. A secondary aim was to supply additional information on the reproductive outcome in women with previously diagnosed PCOS. A longitudinal cohort study with a median follow-up of 120.9 months was conducted, and 31 Caucasian women previously diagnosed with PCOS according to the Rotterdam criteria were re-examined at a median age of 35. Clinical examinations<br />transvaginal ultrasound scans<br />and lipid, E-selectin and sex hormone assessments were performed at the beginning and at the end of the follow-up. It was observed that menstrual cycles became regular and sonographic morphology of ovaries was normalized in 55% and 49% of the participants, respectively (all p &lt<br />0.05). At the final assessment, 55% of the women no longer met the criteria for PCOS (p &lt<br />0.05). The age, follicle-stimulating hormone (FSH) and E-selectin assessed at the baseline were the most important predictors of the PCOS persistence into later years (respectively, OR = 0.84, OR = 0.39, OR = 1.08, all p &lt<br />0.05). Ninety-five percent of the patients who had ever been trying to conceive became pregnant a minimum of once. The women with persistent PCOS had worse metabolic and reproductive parameters compared to the women with resolved PCOS. Positive correlations were found between the number of miscarriages and ovarian volume, LH, androstenedione, 17-hydroxyprogesterone and an increase in E-selectin during the follow-up (R = 0.46, R = 0.59, R = 0.54, R = 0.49, R = 0.47, all p &lt<br />0.05). In conclusion, progressing from the third to the fourth decade is connected with a reduction in PCOS features, which seems to have a great impact on fertility of women with a previous diagnosis of PCOS. FSH and E-selectin, as determined at the initial PCOS diagnosis, had an impact on the disappearance of the syndrome years after.
- Subjects :
- Longitudinal study
medicine.medical_specialty
endocrine system diseases
media_common.quotation_subject
030209 endocrinology & metabolism
Fertility
oligomenorrhea
Article
hyperandrogenism
03 medical and health sciences
0302 clinical medicine
Sex hormone-binding globulin
medicine
PCOS
Androstenedione
media_common
fertility
030219 obstetrics & reproductive medicine
biology
Obstetrics
business.industry
Hyperandrogenism
E-selectin
aging
longitudinal study
nutritional and metabolic diseases
General Medicine
medicine.disease
Polycystic ovary
female genital diseases and pregnancy complications
Natural history
biology.protein
Medicine
business
Hormone
miscarriages
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine
- Accession number :
- edsair.doi.dedup.....04449fad88980ec28552326176b39330