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History of tonsillectomy and risk of oropharyngeal cancer
- Source :
- Oral Oncology, Oral Oncology, Elsevier, 2021, 117, ⟨10.1016/j.oraloncology.2021.105302⟩, Oral Oncology, 2021, 117, pp.105302. ⟨10.1016/j.oraloncology.2021.105302⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Objective: To investigate whether palatine tonsillectomy in youth influences the risk of oropharyngeal cancers (OPC) by assessing the association between history of tonsillectomy and risk of tonsillar, base of tongue (BOT) cancer, and other head and neck cancers (HNC). Materials and Methods: RACKAM was a case-case study comparing frequency of tonsillectomy history in individuals diagnosed with HNC from 2013 to 2018 in 15 centers across France. History of tonsillectomy was defined using combined assessment of patients and rsquo; recollections and surgeons and rsquo; visualizations of tonsil area. OPC subsite-specific odds ratios (OR) of tonsillectomy were calculated using multinomial logistic regression with nonoropharyngeal HNC as reference. Results: 1045 patients were included in the study. Frequency of tonsillectomy was 19.5% in patients with tonsillar cancer (N = 85), 49.3% in BOT (N = 76), 33.8% in other oropharyngeal cancers (N = 202) and 38.0% in non-oropharyngeal HNC (N = 682). History of tonsillectomy was inversely associated with tonsillar cancer (adjusted OR 0.4; 95% CI 0.2 and ndash;0.8), and positively associated with BOT cancer (adjusted OR 1.8; 95% CI 1.1 and ndash;3.1), but was not associated with all OPC combined (adjusted OR 1.1; 95% CI 0.8 and ndash;1.4). Sensitivity analyses considering only patients and rsquo; or surgeons and rsquo; assessments of tonsillectomy provided comparable results. Conclusion: We confirm the long-term protective effect of tonsillectomy performed in youth on future risk of tonsillar cancer, and our study is the second to report a concurrent increased risk of BOT cancer. Our data suggest that tonsillectomy in youth shifts the site of the first diagnosed oropharyngeal tumor and has a limited impact on overall risk of OPC.
- Subjects :
- Cancer Research
medicine.medical_specialty
Tonsillar cancer
Adolescent
medicine.medical_treatment
Palatine Tonsil
Oropharyngeal Tumor
[SDV.CAN]Life Sciences [q-bio]/Cancer
03 medical and health sciences
0302 clinical medicine
Tongue
Internal medicine
Base of the tongue cancer
medicine
Humans
030223 otorhinolaryngology
Head and neck cancer
Tonsillectomy
Oropharyngeal cancer
business.industry
Cancer
Odds ratio
medicine.disease
3. Good health
Oropharyngeal Neoplasms
medicine.anatomical_structure
Tonsil
Oncology
030220 oncology & carcinogenesis
Oral Surgery
business
Subjects
Details
- Language :
- English
- ISSN :
- 13688375
- Database :
- OpenAIRE
- Journal :
- Oral Oncology, Oral Oncology, Elsevier, 2021, 117, ⟨10.1016/j.oraloncology.2021.105302⟩, Oral Oncology, 2021, 117, pp.105302. ⟨10.1016/j.oraloncology.2021.105302⟩
- Accession number :
- edsair.doi.dedup.....043b27094a05acc1d3d6ac59730ae13b