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Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey
- Publication Year :
- 2016
- Publisher :
- AVES, 2016.
-
Abstract
- WOS: 000382992100003<br />PubMed ID: 28331745<br />Objective: Breast cancer is the most common malignancy among Turkish women and the rate of early stage disease is increasing. The Oncotype DX 21-gene assay is predictive of distant recurrence in ER-positive, HER2-negative early breast cancer. We aimed to evaluate the correlations between Recurrence Score (RS) and routine risk factors. Materials and Methods: Ten academic centers across Turkey participated in this prospective trial. Consecutive patients with breast cancer who had pT1-3, pN0-N1mic, ER-positive, and HER2-negative tumors were identified at tumor conferences. Both pre- and post-RS treatment decisions and physician perceptions were recorded on questionnaire forms. Correlations between RS and classic risk factors were evaluated using univariate and multivariate analyses. Results: Ten centers enrolled a total of 165 patients. The median tumor size was 2 cm. Of the 165 patients, 57% had low RS, 35% had intermediate RS, and 8% had high RS, respectively. Multivariate analysis indicated that progesterone receptor (PR) and Ki67 scores were significantly related to RS. Conclusion: Oncotype DX Recurrence Score does not seem to have a significant correlation with the majority of classic risk factors, but it may have a correlation with PR score and Ki67 score.<br />Genomic Health (Inc.; California, USA)<br />Genomic Health (Inc.; California, USA) has provided an educational grant for the genomic testing in this trial.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Multivariate analysis
Recurrence score
Malignancy
Correlation
03 medical and health sciences
Oncotype DX
0302 clinical medicine
Breast cancer
Internal medicine
Progesterone receptor
Medicine
Gynecology
medicine.diagnostic_test
business.industry
Univariate
hormone receptors
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
correlation
Original Article
pathology
business
Ki67
Subjects
Details
- ISSN :
- 28331745
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....043464e96219ee1dd26ad994b350ef7c