Back to Search
Start Over
Delayed-Onset Nodules to Differentially Crosslinked Hyaluronic Acids: Comparative Incidence and Risk Assessment
- Source :
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 45(8)
- Publication Year :
- 2019
-
Abstract
- Robust and long-term data on true incidence of delayed-onset nodules and immune tolerance of hyaluronic acid (HA) fillers are lacking.To characterize the incidence of delayed nodules in Vycross (VYC) HA fillers compared with previously reported FDA and non-FDA data of all HA fillers.The incidence of delayed nodules in all patients who had received VYC fillers in a 12-month period was assessed through a retrospective chart review. Nodule incidence for currently approved nonanimal-stabilized hyaluronic acid (NASHA) fillers was assessed using the FDA Summary of Safety and Effectiveness Data.Overall, 1,029 patients received 1,250 VYC filler treatments. Five patients developed delayed nodules to VOB, with an incidence of 1.0% per patient and 0.8% per syringe. No nodules were observed in patients who received VLR or VOL. All nodules were treated successfully using a combination of intralesional triamcinolone and hyaluronidase. Compared with other currently approved NASHA fillers, VOB is associated with a higher incidence of nodule formation.The introduction of VYC HAs has introduced a new variable that may be changing the immune tolerance of these substances, resulting in a higher incidence of delayed nodules than previously expected.
- Subjects :
- Male
medicine.medical_specialty
Injections, Intradermal
Dermatology
Cosmetic Techniques
Gastroenterology
Risk Assessment
Immune tolerance
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Text mining
Internal medicine
Dermal Fillers
Hyaluronic acid
medicine
Humans
Hyaluronic Acid
Retrospective Studies
business.industry
Incidence (epidemiology)
Delayed onset
Retrospective cohort study
General Medicine
Middle Aged
chemistry
030220 oncology & carcinogenesis
Surgery
Female
Drug Eruptions
business
Risk assessment
Facial Dermatoses
Subjects
Details
- ISSN :
- 15244725
- Volume :
- 45
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
- Accession number :
- edsair.doi.dedup.....042f622e44ccedeb70a6d3ba250c3cb8