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Individualized plasticity autograft mimic with efficient bioactivity inducing osteogenesis
- Source :
- International Journal of Oral Science, Vol 13, Iss 1, Pp 1-8 (2021), International Journal of Oral Science
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- Mineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration. At present, autograft harvest procedures may cause secondary trauma to patients, while bone scaffold materials lack osteogenic activity, resulting in a limited application. Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft, but the explosive release of growth factor may also cause side effects. In this study, we innovatively used platelet-rich fibrin (PRF)-modified bone scaffolds (Bio-Oss®) to replace autograft, and used cytokine (BMP-2) to enhance osteogenesis. Encouragingly, this mixture, which we named “Autograft Mimic (AGM)”, has multiple functions and advantages. (1) The fiber network provided by PRF binds the entire bone scaffold together, thereby shaping the bone grafts and maintaining the space of the defect area. (2) The sustained release of BMP-2 from bone graft promoted bone regeneration continuously. (3) AGM recruited bone marrow mesenchymal stem cells (BMSCs) and promote their proliferation, migration, and osteogenic differentiation. Thus, AGM developed in this study can improve osteogenesis, and provide new guidance for the development of clinical bone grafts.
- Subjects :
- 0301 basic medicine
Biomineralization
Bone Regeneration
medicine.medical_treatment
Cellular differentiation
02 engineering and technology
Fibrin
Article
03 medical and health sciences
Tissue engineering
Osteogenesis
Medicine
Humans
Bone regeneration
Autografts
General Dentistry
biology
Tissue Engineering
Tissue Scaffolds
business.industry
Regeneration (biology)
Growth factor
Mesenchymal stem cell
Cell Differentiation
Mesenchymal Stem Cells
RK1-715
021001 nanoscience & nanotechnology
030104 developmental biology
Cytokine
Dentistry
biology.protein
0210 nano-technology
business
Biomedical materials
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 20493169 and 16742818
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International Journal of Oral Science
- Accession number :
- edsair.doi.dedup.....040d17ace7fbcc063d0c8627fd802018