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Ambient air pollution: a cause of COPD?
- Source :
- European Respiratory Journal
- Publication Year :
- 2013
- Publisher :
- European Respiratory Society (ERS), 2013.
-
Abstract
- The role of ambient air pollution in the development of chronic obstructive pulmonary disease (COPD) is considered to be uncertain. We review the evidence in the light of recent studies. Eight morbidity and six mortality studies were identified. These were heterogeneous in design, characterisation of exposure to air pollution and methods of outcome definition. Six morbidity studies with objectively defined COPD (forced expiratory volume in 1 s/forced vital capacity ratio) were cross-sectional analyses. One longitudinal study defined incidence of COPD as the first hospitalisation due to COPD. However, neither mortality nor hospitalisation studies can unambiguously distinguish acute from long-term effects on the development of the underlying pathophysiological changes. Most studies were based on within-community exposure contrasts, which mainly assess traffic-related air pollution. Overall, evidence of chronic effects of air pollution on the prevalence and incidence of COPD among adults was suggestive but not conclusive, despite plausible biological mechanisms and good evidence that air pollution affects lung development in childhood and triggers exacerbations in COPD patients. To fully integrate this evidence in the assessment, the life-time course of COPD should be better defined. Larger studies with longer follow-up periods, specific definitions of COPD phenotypes, and more refined and source-specific exposure assessments are needed.
- Subjects :
- Pulmonary and Respiratory Medicine
Chronic Obstructive
Pathology
medicine.medical_specialty
Vital capacity
Longitudinal study
Copd patients
Nitrogen Dioxide
adverse effects/statistics /&/ numerical data
Air pollution
Pulmonary disease
medicine.disease_cause
Pulmonary Disease
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
Ozone
0302 clinical medicine
adverse effects/statistics /&/ numer/ical data
Air Pollution
Humans
Medicine
030212 general & internal medicine
Intensive care medicine
Vehicle Emissions
COPD
Ambient air pollution
business.industry
Incidence (epidemiology)
Environmental Exposure
medicine.disease
respiratory tract diseases
3. Good health
Causality
adverse effects/statistics /&/ numerical data, Causality, Environmental Exposure
adverse effects/statistics /&/ numer/ical data, Humans, Nitrogen Dioxide, Ozone, Particulate Matter, Pulmonary Disease
epidemiology, Vehicle Emissions
030228 respiratory system
epidemiology
Particulate Matter
business
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....03fe264e881b3f659a7de486f4b192a8