Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

Subjects

Subjects :

Peptide
Plasma protein binding
Crystallography, X-Ray
Thrombin
Fibrinolytic Agents
Drug Discovery
medicine
Binding site
chemistry.chemical_classification
Cyclohexylamines
Binding Sites
biology
Molecular Structure
Active site
Hydrogen Bonding
Dipeptides
Biochemistry
chemistry
Enzyme inhibitor
Drug Design
biology.protein
Molecular Medicine
Fibrinolytic agent
medicine.drug
Discovery and development of direct thrombin inhibitors
Protein Binding

Details

ISSN :

00222623

Volume :

40

Issue :

6

Database :

OpenAIRE

Journal :

Journal of medicinal chemistry

Accession number :

edsair.doi.dedup.....03fc3790c3d19b0793ccbd6b1e77576a