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Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study
- Source :
- Journal of Clinical Sleep Medicine. 14:1669-1677
- Publication Year :
- 2018
- Publisher :
- American Academy of Sleep Medicine (AASM), 2018.
-
Abstract
- STUDY OBJECTIVES: Researchers have previously reported a possible association between sedative-hypnotics and increased mortality. However, the relationship remains controversial. We investigated the association between sedative-hypnotics and mortality using a large population-based database from the Republic of Korea. METHODS: We used a National Health Insurance Service database. The study population was a 5% random sample of the database from the years 2002– 2015. Individuals who were age 40 years and older were included in the analysis. The sedative-hypnotic users were defined as individuals prescribed 30 or more defined daily doses of sedative-hypnotics per year since January 2004. Sedative-hypnotics were classified based on type and total amount. We estimated the risk of mortality (death from January 2004 to December 2015) using time-dependent Cox regression model adjusted for age, sex, Charlson Comorbidity Index, and psychiatric comorbidity. RESULTS: We identified 180,823 study participants who used sedative-hypnotics and 320,136 nonusers. In a multivariate model, study participants who used sedative-hypnotics had significantly higher mortality risk than nonusers (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.12–1.16). Specifically, study participants who used zolpidem had a higher mortality risk (HR 1.59, 95% CI 1.52–1.67) than nonusers. CONCLUSIONS: Based on the current study results, sedative-hypnotics were associated with an increased risk of mortality, especially in study participants who used zolpidem. CITATION: Choi JW, Lee J, Jung SJ, Shin A, Lee YJ. Use of sedative-hypnotics and mortality: a population-based retrospective cohort study. J Clin Sleep Med. 2018;14(10):1669–1677.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Zolpidem
Pediatrics
medicine.medical_specialty
medicine.drug_class
Population based
03 medical and health sciences
Sex Factors
0302 clinical medicine
Risk Factors
Republic of Korea
Humans
Hypnotics and Sedatives
Medicine
030212 general & internal medicine
Mortality
Proportional Hazards Models
Retrospective Studies
business.industry
Age Factors
Retrospective cohort study
Middle Aged
Scientific Investigations
030227 psychiatry
Neurology
Sedative
Multivariate Analysis
Female
Neurology (clinical)
business
medicine.drug
Subjects
Details
- ISSN :
- 15509397 and 15509389
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Sleep Medicine
- Accession number :
- edsair.doi.dedup.....03ef61b81748fdbc7513a3cb51d48ea7