Recent Advances in the Synthesis of SCF2H- and SCF2FG-Containing Molecules

International audience; In recent years, much interest has been paid to difluoromethylthiolated molecules as the “SCF2” moiety is a key motif in drug and agrochemical research. Consequently, the development of versatile strategies for the selective synthesis of SCF2H- and SCF2FG-containing molecules (FG= functional group) has attracted a lot of attention and inspired the scientific community to design new tools. This Minireview highlights the major progress made in this field. Particularly, methodologies developed for the difluoromethylation of sulfur-containing molecules and the direct construction of CSCF2 bonds in various classes of compounds are showcased and discussed.