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Anti-polysaccharide and anti-diphtheria protective antibodies after 13-valent pneumococcal conjugate vaccination in rheumatoid arthritis patients under immunosuppressive therapy
- Publication Year :
- 2018
- Publisher :
- Academic Press Inc., 2018.
-
Abstract
- Immunogenicity of 13-valent pneumococcal polysaccharide (PnPS) conjugate vaccine (PCV13) was evaluated in 38 rheumatoid arthritis patients under immunosuppressive treatment and 20 healthy controls (HC). Antibodies to all PnPS and diphtheria-toxin analogue conjugate protein were measured pre- (T0), 1 (T1), 6 (T2), 12 (T3) months post-immunization. Patients and HC had similar response to individual PnPS. Mean antibody levels to all PnPS but one doubled at T1 compared with T0, with T3 persistence for only 8-7/13 PnPS. Baseline antibody levels was inversely associated with the rate of responders at T1 (T1/T0≥2) to 11/13 PnPS. Few subjects reached protective IgG levels against some serotypes frequently isolated in Italian patients with invasive pneumococcal disease. Antibody response was not influenced by therapy, except the one to PS7F, which was reduced by tumor necrosis factor-α-inhibitors. Vaccination increased also anti-diphtheria IgG. Despite this study substantially confirmed the PCV13 immunogenicity in immunocompromised patients, it also revealed some limitations.
- Subjects :
- Male
Serotype
13-valent pneumococcal conjugate vaccine
Immunology
Pneumococcal Infections
Arthritis, Rheumatoid
Pneumococcal Vaccines
Immunocompromised Host
03 medical and health sciences
0302 clinical medicine
Conjugate vaccine
medicine
Humans
Immunology and Allergy
030212 general & internal medicine
Rheumatoid arthritis
Aged
030203 arthritis & rheumatology
biology
business.industry
Corynebacterium diphtheriae
Diphtheria
Immunogenicity
Polysaccharides, Bacterial
Vaccination
Middle Aged
medicine.disease
Antibodies, Bacterial
Immunity, Humoral
Immunosuppressive therapy
Italy
Antibody persistence
Immunoglobulin G
biology.protein
Female
Tumor necrosis factor alpha
Antibody
business
Immunosuppressive Agents
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....03d9a18bb2158bb064a136035fb61b9b