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Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: Subversion towards autoimmunity by proteinase 3
- Source :
- European Journal of Clinical Investigation, European Journal of Clinical Investigation, Wiley, 2018, 48 (Suppl 2), pp.e12990. ⟨10.1111/eci.12990⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Neutrophils are critically involved in host defence and they also modulate the inflammatory process. Turning the inflammatory response towards a resolutive outcome requires a dialogue between apoptotic neutrophils and proresolving macrophages through complex key molecular interactions controlling efferocytosis, anti-inflammatory reprogramming and ultimately immune regulation. In this review, we will first focus on recent molecular analyses aiming at characterizing the role of proteins expressed on apoptotic neutrophils and their cognate partners expressed on macrophages in the resolution of inflammation. These will include chemokine receptors and their ligands and annexin A1 and its receptor FPR2. We will next depict how the structural and enzymatic properties of proteinase 3 (PR3), the autoantigen in vasculitis, allow its expression on apoptotic neutrophils, which in turn affects efferocytosis and immune response associated with the clearance of apoptotic cells. This example illustrates that the fate of apoptotic neutrophils directly influences the resolution of inflammation and immune responses thereby potentially contributing to systemic and nonresolving inflammation as well as autoimmunity.
- Subjects :
- 0301 basic medicine
Neutrophils
Myeloblastin
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Inflammation
Apoptosis
Autoimmunity
Biology
medicine.disease_cause
Biochemistry
Autoimmune Diseases
03 medical and health sciences
Chemokine receptor
Mice
Immune system
Phagocytosis
Proteinase 3
medicine
Macrophage
Animals
Humans
Efferocytosis
Macrophages
General Medicine
Macrophage Activation
Cell biology
030104 developmental biology
Cytokines
medicine.symptom
Annexin A1
Subjects
Details
- Language :
- English
- ISSN :
- 00142972 and 13652362
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation, European Journal of Clinical Investigation, Wiley, 2018, 48 (Suppl 2), pp.e12990. ⟨10.1111/eci.12990⟩
- Accession number :
- edsair.doi.dedup.....03d92f2eccb74f949c1e4192cb71dedf