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Behavioral effects of urotensin-II centrally administered in mice
- Source :
- Psychopharmacology, Psychopharmacology, Springer Verlag, 2005, 183 (1), pp.103-117. ⟨10.1007/s00213-005-0140-2⟩
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- International audience; Urotensin-II (U-II) receptors are widely distributed in the central nervous system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, the behavioral effects of centrally administered U-II have received little attention. In the present study, we tested the effects of i.c.v. injections of U-II on behavioral, metabolic, and endocrine responses in mice. Administration of graded doses of U-II (1-10,000 ng/mouse) provoked: (1) a dose-dependent reduction in the number of head dips in the hole-board test; (2) a dose-dependent reduction in the number of entries in the white chamber in the black-and-white compartment test, and in the number of entries in the central platform and open arms in the plus-maze test; and (3) a dose-dependent increase in the duration of immobility in the forced-swimming test and tail suspension test. Intracerebroventricular injection of U-II also caused an increase in: food intake at doses of 100 and 1,000 ng/mouse, water intake at doses of 100-10,000 ng/mouse, and horizontal locomotion activity at a dose of 10,000 ng/mouse. Whatever was the dose, the central administration of U-II had no effect on body temperature, nociception, apomorphine-induced penile erection and climbing behavior, and stress-induced plasma corticosterone level. Taken together, the present study demonstrates that the central injection of U-II at doses of 1-10,000 ng/mouse induces anxiogenic- and depressant-like effects in mouse. These data suggest that U-II may be involved in some aspects of psychiatric disorders.
- Subjects :
- Male
Time Factors
MESH: Body Temperature
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
MESH: Amino Acid Sequence
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
MESH: Eating
Body Temperature
MESH: Dose-Response Relationship, Drug
Eating
Mice
chemistry.chemical_compound
0302 clinical medicine
MESH: Behavior, Animal
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
MESH: Animals
Receptor
0303 health sciences
Behavior, Animal
Nociception
medicine.anatomical_structure
MESH: Exploratory Behavior
MESH: Injections, Intraventricular
Locomotion
MESH: Drinking
medicine.medical_specialty
Urotensins
Molecular Sequence Data
Central nervous system
Drinking
MESH: Locomotion
03 medical and health sciences
Internal medicine
medicine
Animals
Endocrine system
Amino Acid Sequence
Maze Learning
MESH: Mice
Injections, Intraventricular
030304 developmental biology
Pharmacology
MESH: Molecular Sequence Data
MESH: Urotensins
Dose-Response Relationship, Drug
business.industry
MESH: Maze Learning
MESH: Time Factors
MESH: Male
Tail suspension test
Prolactin
Endocrinology
Anxiogenic
chemistry
Exploratory Behavior
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Urotensin-II
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14322072 and 00333158
- Volume :
- 183
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....03d9229bbb28dec2107575ca5cbf11a1