Role of perlecan in chondrogenic, osteogenic and adipogenic differentiation of synovial mesenchymal calls

s / Osteoarthritis and Cartilage 22 (2014) S57–S489 S439 To explore this, the aim of this study was to evaluate the impact of a FR program on the variation in muscle/lean mass and fat mass in patients with chronic low back pain. Patients and methods: Design: longitudinal uncontrolled French monocentric prospective study. Patients: All patients with chronic low back pain who participated in the FR program between January 2010 and March 2013 where included. Intervention: The FR program was carried out over a period of 4 weeks, 5 days aweek and included 3 hours per day of intensive physical training as well as patient education, relaxation etc through a multidisciplinary approach. Assessment: DXA was performed at baseline, at 1 month (end of the FR program) and at 6 months. The primary endpoint was the absolute variation in the muscle mass (or lean mass) calculated by DXA between baseline and 6 months. Variations in fat mass and variations as 1 month were also analysed. Statistical analysis: parametric paired tests (student’s t) and nonparametric paired test (Wilcoxon) in the total population and based on the body mass index (BMI) at inclusion : normal weight versus overweight or obesity (BMI>25kg /m2). Only patients with DXA available at baseline and 6 months were included in the analyses (no imputation of missing data). Results: In all, 95 patients were included, 40 men and 55 women: mean age 41 ( 8.4) years, mean BMI 26.6kg/m2, 38 (60%) where overweight or obese. At 1 month, there was an increase in lean mass (mean change þ1.3kg) and a decrease in fat mass (mean change -0.6kg) in the total population and in the subgroups according to BMI (p all