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Influence of prosthesis-related factors on the occurrence of early leaflet thrombosis after transcatheter aortic valve implantation
- Source :
- European heart journal. Cardiovascular Imaging. 21(10)
- Publication Year :
- 2020
-
Abstract
- Aims Early leaflet thrombosis (LT) is a well-described phenomenon after transcatheter aortic valve implantation (TAVI) with an incidence around 15%. Data about predictors of LT are scarce. The purpose of the study was to investigate the influence of prosthesis-related factors on the occurrence of LT. Materials and results Fusion imaging of pre- and post-procedural computed tomography angiography was performed in 55 TAVI patients with LT and 140 selected patients as control groups (85 patients in an unmatched and 55 in a matched control) to obtain a 3D reconstruction of the transcatheter heart valve (THV) within the native annulus region. All patients received a balloon-expandable Sapien 3 THV. The THV length above and below the native annulus was measured within the fused images to assess the implantation depth. The deployed THV area was quantified on three heights (left ventricular outflow tract end, stent centre, and aortic end) to determine the average expansion of the prosthesis as percent of the nominal area. We also calculated the extent of prosthesis waist in percent of maximum area. After multivariate adjustment, the extent of THV waist [odds ratio (OR) per 10% (confidence interval, CI) 0.636 (0.526–0.769), P Conclusion Besides the absence of previous oral anticoagulation, a less pronounced waist of the implanted THV was a prosthesis-position-related independent predictor of LT after TAVI using the Sapien 3.
- Subjects :
- medicine.medical_specialty
Waist
Computed Tomography Angiography
medicine.medical_treatment
030204 cardiovascular system & hematology
Prosthesis Design
Prosthesis
Transcatheter Aortic Valve Replacement
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Ventricular outflow tract
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Heart valve
Computed tomography angiography
medicine.diagnostic_test
business.industry
Stent
Thrombosis
General Medicine
Odds ratio
Aortic Valve Stenosis
medicine.disease
medicine.anatomical_structure
Treatment Outcome
Aortic Valve
Heart Valve Prosthesis
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 20472412
- Volume :
- 21
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- European heart journal. Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....03c98b3caba8b9cb76daa657c75265fb