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Key pathways and genes controlling the development and progression of clear cell renal cell carcinoma (ccRCC) based on gene set enrichment analysis
- Source :
- International Urology and Nephrology
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Background Clear-cell renal cell carcinoma (ccRCC) is one of the most common types of kidney cancer in adults; however, its causes are not completely understood. The study was designed to filter the key pathways and genes associated with the occurrence or development of ccRCC, acquaint its pathogenesis at gene and pathway level, to provide more theory evidence and targeted therapy for ccRCC. Methods Gene set enrichment analysis (GSEA) and meta-analysis (Meta) were used to screen the critical pathways and genes which may affect the occurrence and progression of ccRCC on the transcription level. Corresponding pathways of significant genes were obtained with the online website DAVID (http://david.abcc.ncifcrf.gov/). Results Thirty seven consistent pathways and key genes in these pathways related to ccRCC were obtained with combined GSEA and meta-analysis. These pathways were mainly involved in metabolism, organismal systems, cellular processes and environmental information processing. Conclusion The gene pathways that we identified could provide insight concerning the development of ccRCC. Further studies are needed to determine the biological function for the positive genes.
- Subjects :
- Nephrology
Gene set enrichment analysis
medicine.medical_specialty
Pathology
Urology
medicine.medical_treatment
Targeted therapy
Pathogenesis
Key pathways
Renal cell carcinoma
Internal medicine
medicine
Humans
Carcinoma, Renal Cell
Gene
Urology - Original Paper
business.industry
Gene Expression Profiling
medicine.disease
Kidney Neoplasms
Gene Expression Regulation, Neoplastic
Meta-analysis
Clear cell renal cell carcinoma
Clear-cell renal cell carcinoma (ccRCC)
Disease Progression
Cancer research
business
Kidney cancer
Signal Transduction
Subjects
Details
- ISSN :
- 15732584 and 03011623
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- International Urology and Nephrology
- Accession number :
- edsair.doi.dedup.....03c4c698b2c2092f9a3334eb18e5eef8