Nerve-mediated antidiuresis and antinatriuresis after air-jet stress is modulated by angiotensin II

A putative interaction between angiotensin II (Ang II) and the sympathetic nervous system within the kidney has been reported. We tested the hypothesis in conscious rats that endogenous Ang II modulates the renal effects of a stress-induced increase in sympathetic nerve activity. We recorded mean arterial blood pressure, heart rate, renal sympathetic nerve activity, renal hemodynamics, urine volume, and urinary sodium content in conscious rats. We used the Ang II type 1 receptor blocker ZD 7155 to inhibit the effects of endogenous Ang II. Ten minutes of air-jet stress increased renal sympathetic nerve activity by 98±4% (n=6) without changing systemic hemodynamics. Air-jet stress reduced urine volume (from 31±3 to 8±4 μL/min per gram kidney weight, P P