Back to Search
Start Over
Skeletal muscle resting membrane potential in potassium deficiency
- Source :
- The Journal of clinical investigation. 52(12)
- Publication Year :
- 1973
-
Abstract
- The resting transmembrane potential of skeletal muscle (E(m)) is thought to be a function of the ratio of intracellular to extracellular potassium concentration ([K(i)]/[K(o)]). In potassium deficiency, the fall of [K(i)] is proportionately less than the fall of [K(o)], thus theoretically predicting a rise of E(m). To examine this theory and to characterize E(m) in kaliopenic myopathy, muscle composition and E(m) were measured during moderate (n = 5) and severe (n = 11) K deficiency in the dog and compared with measurements in the severely K-deficient rat (n = 10). Mean measured E(m) rose during moderate K deficiency in four of five dogs (-85.4 to -94.6 mV) and during severe K deficiency in the rat (-89.1 to -94.9 mV). Both values closely approximated the increase in E(m) predicted by the Goldman equation. In contrast, during severe K deficiency in the dog, a significant decline (P < 0.001) of mean E(m) to -55 mV was observed.Since skeletal myopathy and paralysis do not occur in the rat as a consequence of K deficiency, the observation that E(m) falls as paralysis occurs in the unexercised dog suggests that alteration of muscle membrane function may play a role in kaliopenic myopathy. Such an event could explain the ease with which frank muscle necrosis may be induced by exercise in the K-deficient dog.
- Subjects :
- medicine.medical_specialty
Sodium
Potassium
Biopsy
chemistry.chemical_element
Membrane Potentials
Dogs
Chlorides
Muscular Diseases
Internal medicine
medicine
Animals
Myopathy
Potassium Deficiency
Membrane potential
Acid-Base Equilibrium
Electromyography
Muscles
Skeletal muscle
Water
General Medicine
Anatomy
Articles
Rats
Endocrinology
medicine.anatomical_structure
chemistry
Potassium deficiency
medicine.symptom
Intracellular
Muscle contraction
Muscle Contraction
Subjects
Details
- ISSN :
- 00219738
- Volume :
- 52
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical investigation
- Accession number :
- edsair.doi.dedup.....03b89d96f3db66c6eec79d49f7c1691c