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Recommended diagnostic criteria for paraneoplastic neurological syndromes
- Source :
- Journal of Neurology Neurosurgery and Psychiatry, 75, 1135-1140. BMJ Publishing Group
- Publication Year :
- 2004
-
Abstract
- Background: Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate “true” PNS from neurological syndromes that are coincidental with a cancer. Objective: To provide more rigorous diagnostic criteria for PNS. Methods: An international panel of neurologists interested in PNS identified those defined as “classical” in previous studies. The panel reviewed the existing diagnostic criteria and recommended new criteria for those in whom no clinical consensus was reached in the past. The panel reviewed all reported onconeural antibodies and established the conditions to identify those that would be labelled as “well characterised”. The antibody information was obtained from published work and from unpublished data from the different laboratories involved in the study. Results: The panel suggest two levels of evidence to define a neurological syndrome as paraneoplastic: “definite” and “possible” . Each level can be reached combining a set of criteria based on the presence or absence of cancer and the definitions of “classical” syndrome and “well characterised” onconeural antibody. Conclusions: The proposed criteria should help clinicians in the classification of their patients and the prospective and retrospective analysis of PNS cases.
- Subjects :
- Paper
Pediatrics
medicine.medical_specialty
Pathology
animal structures
Neurology
Neurological disability
International Cooperation
MEDLINE
Immunologic Tests
Malignancy
Antibodies
Diagnosis, Differential
Cerebrospinal fluid
Reference Values
Neoplasms
medicine
Neurological syndrome
Humans
Neoplasm
biology
business.industry
Limbic encephalitis
Cancer
Evidence-based medicine
medicine.disease
Paraneoplastic cerebellar degeneration
Editorial Commentary
Psychiatry and Mental health
nervous system
Reference values
Practice Guidelines as Topic
biology.protein
Surgery
sense organs
Neurology (clinical)
Antibody
Differential diagnosis
business
Antibody reactivity
Paraneoplastic Syndromes, Nervous System
Subjects
Details
- ISSN :
- 00223050
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology Neurosurgery and Psychiatry, 75, 1135-1140. BMJ Publishing Group
- Accession number :
- edsair.doi.dedup.....03b5b75b6574d9dde61de890c346e855