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The effect of Liv-52 on liver ischemia reperfusion damage in rats
- Source :
- BMC Pharmacology & Toxicology, BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-9 (2020)
- Publication Year :
- 2019
- Publisher :
- Research Square Platform LLC, 2019.
-
Abstract
- Background Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats. Methods Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals. Results Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically. Conclusions Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.
- Subjects :
- Male
Antioxidant
medicine.medical_treatment
Injury
Pharmacology
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
Pharmacology (medical)
Group level
Glutathione Transferase
0303 health sciences
biology
virus diseases
Alanine Transaminase
Liver ischemia
Glutathione
Drug Combinations
Glutathione Reductase
Liver
030220 oncology & carcinogenesis
Myeloperoxidase
Reperfusion Injury
Research Article
Liv-52
Ischemia
Superoxide dismutase
03 medical and health sciences
lcsh:RA1190-1270
Lactate dehydrogenase
medicine
Animals
Aspartate Aminotransferases
Rats, Wistar
030304 developmental biology
lcsh:Toxicology. Poisons
Peroxidase
Glutathione Peroxidase
L-Lactate Dehydrogenase
business.industry
Plant Extracts
Superoxide Dismutase
lcsh:RM1-950
medicine.disease
Ischemia reperfusion
lcsh:Therapeutics. Pharmacology
chemistry
biology.protein
Rat
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BMC Pharmacology & Toxicology, BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-9 (2020)
- Accession number :
- edsair.doi.dedup.....03b511f1c6215aa67e8c9e8973439835