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Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome
- Source :
- Nature Microbiology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Bacteriophages have important roles in the ecology of the human gut microbiome but are under-represented in reference databases. To address this problem, we assembled the Metagenomic Gut Virus catalogue that comprises 189,680 viral genomes from 11,810 publicly available human stool metagenomes. Over 75% of genomes represent double-stranded DNA phages that infect members of the Bacteroidia and Clostridia classes. Based on sequence clustering we identified 54,118 candidate viral species, 92% of which were not found in existing databases. The Metagenomic Gut Virus catalogue improves detection of viruses in stool metagenomes and accounts for nearly 40% of CRISPR spacers found in human gut Bacteria and Archaea. We also produced a catalogue of 459,375 viral protein clusters to explore the functional potential of the gut virome. This revealed tens of thousands of diversity-generating retroelements, which use error-prone reverse transcription to mutate target genes and may be involved in the molecular arms race between phages and their bacterial hosts.<br />Almost 190,000 draft-quality DNA virus genomes are recovered by mining more than 11,000 deposited human stool metagenomes to improve resources for understanding the human gut virome.
- Subjects :
- Resource
Microbiology (medical)
Bacteroidia
Viral protein
viruses
Immunology
Genome, Viral
Biology
medicine.disease_cause
Applied Microbiology and Biotechnology
Microbiology
Genome
CRISPR Spacers
Virus
Feces
Viral Proteins
03 medical and health sciences
0302 clinical medicine
Catalogs as Topic
Genetics
medicine
Humans
Bacteriophages
Human virome
Microbiome
Data mining
Phylogeny
030304 developmental biology
0303 health sciences
Bacteria
DNA Viruses
Genetic Variation
Cell Biology
biology.organism_classification
Archaea
Gastrointestinal Microbiome
Metagenomics
DNA, Viral
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20585276
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Nature Microbiology
- Accession number :
- edsair.doi.dedup.....03af3237881c7688c8d9836f049106d8