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Contribution of bone turnover markers to the variation in bone mineral density: a study in Vietnamese men and women
- Source :
- Osteoporosis International. 29:2739-2744
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The present cross-sectional study constructed reference ranges for bone resorption marker beta isomerized form of C-terminal crosslinking telopeptides of type I collagen (beta-CTX) and bone formation marker procollagen type 1 N-terminal propeptide (PINP) for the Vietnamese population. We have further shown that for a given age and weight, higher levels of beta-CTX were significantly associated with bone mineral density in men and women.Normal bone is constantly renewed by two opposing processes of resorption and formation which can be reflected by bone turnover markers (BTMs). This study sought to define the contribution of BTMs to the variation in bone mineral density (BMD) in normal individuals.The study involved 205 men and 432 women aged between 18 and 87, who were randomly selected from various districts within Ho Chi Minh City, Vietnam. Fasting serum levels of PINP and beta-CTX were determined by electrochemiluminescence (Roche, ECLIA). BMD at the lumbar spine (LS) and femoral neck (FN) was measured by dual-energy x-ray absorptiometry (Hologic, Waltham, MA, USA).Among those aged 50 years, women had lower PINP and beta-CTX levels than men, but among those aged 50 years, women had higher PINP and beta-CTX levels than men. In the multiple linear regression analysis, beta-CTX-but not PINP-was significantly associated with both femoral neck (P = 0.008) and lumbar spine BMD (P = 0.008) and the association was independent of gender, age, and body weight. The proportion of variance in BMD attributable to beta-CTX was 1% for femoral neck BMD and 2% for lumbar spine BMD.The elevation in bone formation marker PINP and bone resorption marker beta-CTX in postmenopausal women was greater than in elderly men. However, only beta-CTX was modestly but significantly associated with BMD.
- Subjects :
- Adult
Male
musculoskeletal diseases
Aging
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
Osteoporosis
Population
030209 endocrinology & metabolism
Collagen Type I
Bone resorption
Bone remodeling
Young Adult
03 medical and health sciences
Absorptiometry, Photon
0302 clinical medicine
Bone Density
Internal medicine
Humans
Medicine
education
Aged
Femoral neck
Aged, 80 and over
030203 arthritis & rheumatology
Bone mineral
Sex Characteristics
education.field_of_study
Lumbar Vertebrae
Femur Neck
business.industry
Middle Aged
medicine.disease
Peptide Fragments
Resorption
Cross-Sectional Studies
medicine.anatomical_structure
Endocrinology
Orthopedic surgery
Female
Bone Remodeling
Peptides
business
Biomarkers
Procollagen
Subjects
Details
- ISSN :
- 14332965 and 0937941X
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Osteoporosis International
- Accession number :
- edsair.doi.dedup.....03ac2fa10a635f4f18c3eaa99381dc5e