Precise Temporal Control of Interferential Neural Stimulation via Phase Modulation

Objective Noninvasive neural stimulation via temporally interferential (TI) electrical field is currently an area of interest as a noninvasive method of brain stimulation. The major limitation of TI stimulation is the difficulty of precise temporal control of the stimulation, due to the nature of the sinusoidal envelope generated by the interference. The purpose of this study was to investigate the possibility of improving interferential stimulation by introducing precise temporal control using phase modulation. Methods In conventional TI, a sinusoidal current is applied to two electrode pairs with slightly different frequencies, to cause interference. In this paper we describe phase modulation interference (PMI). Instead of shifting frequency, the phase of a sinusoidal wave was partially modulated, causing a transient increase or decrease of the envelope. The spatial distribution of envelope modulation amplitude by TI and PMI was visualized using both electromagnetic simulation and actual measurement using tissue phantom. Results The measured voltage transient in the tissue phantom produce a precise, temporally controlled pulse-like envelope using PMI. The spatial distributions of the amplitude of the envelope modulation by TI and PMI did not differ significantly, and were consistent with electromagnetic simulation. Conclusion PMI allows precise temporal control of interferential stimulation, thus increasing the practical utility of interferential stimulation. Significance PMI improves interferential stimulation, allowing more temporally precise stimulation to neural tissue located distantly from the stimulating electrodes.