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Risk and Fate of Cerebral Embolism After Transfemoral Aortic Valve Implantation

Authors :
Andreas Müller
Justine Kocurek
Hans H. Schild
Rolf Fimmers
Daniel Thomas
Nikos Werner
Georg Nickenig
Christoph Hammerstingl
Jörg O. Schwab
Alexander Ghanem
Fritz Mellert
C. P. Nähle
Source :
Journal of the American College of Cardiology. 55:1427-1432
Publication Year :
2010
Publisher :
Elsevier BV, 2010.

Abstract

Objectives The aim of this study was prospective investigation of silent and clinically apparent cerebral embolic events and neurological impairment after transfemoral aortic valve implantation (TAVI). Background TAVI is a novel therapeutic approach for multimorbid patients with severe aortic stenosis. We investigated peri-interventional cerebral embolism with diffusion-weighted magnetic resonance imaging (DW-MRI) and its relationship to clinical and serologic parameters of brain injury. Methods Cerebral DW-MRI was performed before, directly, and 3 months after TAVI with the current third-generation self-expanding CoreValve (Medtronic, Minneapolis, Minnesota) prosthesis. At the timepoints of the serial MRI studies, focal neurological impairment was assessed according to the National Institutes of Health Stroke Scale (NIHSS), and serum concentration of neuron-specific enolase (NSE), a marker of the volume of brain tissue involved in an ischemic event, were determined. Results Thirty patients were enrolled; 22 completed the imaging protocol. Three patients (10%) had new neurological findings after TAVI, of whom only 1 (3.6%) had a permanent neurological impairment. Of the 22 TAVI patients with complete imaging data, 16 (72.7%) had 75 new cerebral lesions after TAVI presumed to be embolic. The NIHSS and NSE were not correlated with DW-MRI lesions. Conclusions The incidence of clinically silent peri-interventional cerebral embolic lesions after TAVI is high. However, in this cohort of 30 patients, the incidence of persistent neurological impairment was low. (Incidence and Severity of Silent and Apparent Cerebral Embolism After Conventional and Minimal-invasive Transfemoral Aortic Valve Replacement; NCT00883285 )

Details

ISSN :
07351097
Volume :
55
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi.dedup.....039fe98d01734ca94f096cd3cba6ecc8
Full Text :
https://doi.org/10.1016/j.jacc.2009.12.026